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Year Number of Results
2004 1
2009 1
2011 1
2012 1
2013 5
2014 2
2015 4
2016 3
2017 8
2018 4
2019 5
2020 1
2021 1
2022 1
2024 1

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34 results

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Page 1
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He L, Gao J, Ding Y, Liu Y, Xu Z, Li Z, Yang Z, Li R, Xue X, Gao Y, Yue F, Zhang XH, Hu G, Wang Y, Li Y, Chen G, Siwko S, Gartland A, Wang N, Xiao J, Liu M, Luo J. Yue Z, et al. J Clin Invest. 2022 Jan 18;132(2):e144579. doi: 10.1172/JCI144579. J Clin Invest. 2022. PMID: 34847079 Free PMC article.
In clinical samples, RSPO2, LGR4, and DKK1 expression showed a positive correlation with BCa bone metastasis. Furthermore, soluble LGR4 extracellular domain (ECD) protein, acting as a decoy receptor for RSPO2 and RANKL, significantly alleviated bone metastasis and o …
In clinical samples, RSPO2, LGR4, and DKK1 expression showed a positive correlation with BCa bone metastasis. Furthermore, soluble LG …
The inhibition of YTHDF3/m(6)A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.
Zhong S, Guo Q, Chen X, Luo X, Long Y, Chong T, Ye M, He H, Lu A, Ao K, Yin M, Xu A, Li X, Hao Y, Guo X. Zhong S, et al. Int J Biol Sci. 2024 Jan 12;20(3):916-936. doi: 10.7150/ijbs.87203. eCollection 2024. Int J Biol Sci. 2024. PMID: 38250152 Free PMC article.
The lipid synthesis of fatty acid (FA) represents a significant hallmark in the occurrence and progression of malignant tumor, which are associated with lymph node (LN) metastasis. Elucidation of the molecular mechanisms underlying LN metastasis could provide therap …
The lipid synthesis of fatty acid (FA) represents a significant hallmark in the occurrence and progression of malignant tumor, which are ass …
MiR-30a suppresses clear cell renal cell carcinoma proliferation and metastasis by targeting LRP6.
Ren Y, Zhang L, Zhang W, Gao Y. Ren Y, et al. Hum Cell. 2021 Mar;34(2):598-606. doi: 10.1007/s13577-020-00472-1. Epub 2021 Jan 5. Hum Cell. 2021. PMID: 33400244
Mechanistically, the dual-luciferase reporter, RNA immunoprecipitation and western blot assays confirmed that miR-30a directly targeted the 3'-untranslated regions of LRP6 to inhibit its expression. Further, miR-30a-mediated effect was partially reversed by co-transfection …
Mechanistically, the dual-luciferase reporter, RNA immunoprecipitation and western blot assays confirmed that miR-30a directly targeted the …
GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6.
Xiong H, Xiao H, Luo C, Chen L, Liu X, Hu Z, Zou S, Guan J, Yang D, Wang K. Xiong H, et al. Exp Cell Res. 2019 Oct 1;383(1):111493. doi: 10.1016/j.yexcr.2019.07.006. Epub 2019 Jul 13. Exp Cell Res. 2019. PMID: 31310747
Importantly, we found that GPR78 promoted maturation of LRP6, while knockdown of GRP78 led to LRP6 misfolding and endoplasmic reticulum-associated degradation (ERAD). Consequently, the levels of mature LRP6 were reduced, and Wnt/HOXB9 signaling was inhibited. …
Importantly, we found that GPR78 promoted maturation of LRP6, while knockdown of GRP78 led to LRP6 misfolding and endoplasmic …
Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion.
Ma C, Luo C, Yin H, Zhang Y, Xiong W, Zhang T, Gao T, Wang X, Che D, Fang Z, Li L, Xie J, Huang M, Zhu L, Jiang P, Qi W, Zhou T, Yang Z, Wang W, Ma J, Gao G, Yang X. Ma C, et al. Gastric Cancer. 2018 Jul;21(4):617-631. doi: 10.1007/s10120-017-0787-5. Epub 2017 Dec 14. Gastric Cancer. 2018. PMID: 29243194
BACKGROUND: Tumor-induced lymphangiogenesis and lymphatic metastasis are predominant during the metastasis of many types of cancers. ...Mechanically, kallistatin suppressed the lymphangiogenesis and lymphatic metastasis by downregulating VEGF-C expression and …
BACKGROUND: Tumor-induced lymphangiogenesis and lymphatic metastasis are predominant during the metastasis of many types of ca …
MiR-126-3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2.
Du C, Lv Z, Cao L, Ding C, Gyabaah OA, Xie H, Zhou L, Wu J, Zheng S. Du C, et al. J Transl Med. 2014 Sep 22;12:259. doi: 10.1186/s12967-014-0259-1. J Transl Med. 2014. PMID: 25240815 Free PMC article.
Furthermore, overexpression of miR-126-3p significantly reduced the volume of tumor and microvessel density in vivo. LRP6 and PIK3R2 were identified as targets of miR-126-3p. Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis …
Furthermore, overexpression of miR-126-3p significantly reduced the volume of tumor and microvessel density in vivo. LRP6 and PIK3R2 …
LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.
Ren DN, Chen J, Li Z, Yan H, Yin Y, Wo D, Zhang J, Ao L, Chen B, Ito TK, Chen Y, Liu Z, Li Y, Yang J, Lu X, Peng Y, Pan L, Zhao Y, Liu S, Zhu W. Ren DN, et al. Nat Commun. 2015 Apr 22;6:6906. doi: 10.1038/ncomms7906. Nat Commun. 2015. PMID: 25902418 Free article.
Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain. ...Furthermore, the expression level of membrane LRP5/6 correlates inversely with …
Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this …
MiR-146b-5p promotes metastasis and induces epithelial-mesenchymal transition in thyroid cancer by targeting ZNRF3.
Deng X, Wu B, Xiao K, Kang J, Xie J, Zhang X, Fan Y. Deng X, et al. Cell Physiol Biochem. 2015;35(1):71-82. doi: 10.1159/000369676. Epub 2015 Jan 2. Cell Physiol Biochem. 2015. PMID: 25547151 Free article.
In the present study, we showed that miR-146b-5p is upregulated in PTC with lymph node metastasis. METHODS: A computational search and luciferase assay identified zinc RING finger 3 (ZNRF3), a negative regulator of Wnt/beta-catenin signaling, as a direct target of miR-146b …
In the present study, we showed that miR-146b-5p is upregulated in PTC with lymph node metastasis. METHODS: A computational search an …
Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.
Ma J, Lu W, Chen D, Xu B, Li Y. Ma J, et al. J Cell Biochem. 2017 Sep;118(9):2968-2976. doi: 10.1002/jcb.25956. Epub 2017 May 30. J Cell Biochem. 2017. PMID: 28247948 Free PMC article.
We herein demonstrated that LRP6 expression is up-regulated in human triple negative breast cancer (TNBC) patients and human TNBC cell lines, and that knockdown of LRP6 expression and treatment of recombinant Mesd protein (a specific inhibitor of LRP6) signif …
We herein demonstrated that LRP6 expression is up-regulated in human triple negative breast cancer (TNBC) patients and human TNBC cel …
RASSF10 suppresses lung cancer proliferation and invasion by decreasing the level of phosphorylated LRP6.
Han X, Dong Q, Wu J, Luo Y, Rong X, Han Q, Zheng X, Wang E. Han X, et al. Mol Carcinog. 2019 Jul;58(7):1168-1180. doi: 10.1002/mc.23000. Epub 2019 Mar 4. Mol Carcinog. 2019. PMID: 30834575
However, we found that RASSF10 had no influence on Hippo signaling, while RASSF10 bound to LRP6 via the coiled-coil domains and reduced p-LRP6 level, eventually prohibiting beta-catenin nuclear translocation. However, deleting the coiled-coil domains ablated this fu …
However, we found that RASSF10 had no influence on Hippo signaling, while RASSF10 bound to LRP6 via the coiled-coil domains and reduc …
34 results